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Loscalzo Lab Publications


Inbal A, Gurevitz O, Tamarin I, Eskaraev R, Chetrit A, Novicov I, Feldman M, Varon D, Eldar M, Loscalzo J.  Unique antiplatelet effects of a novel S-nitrosoderivative of a recombinant fragment of von Willebrand factor, AR545C: in vitro and ex vivo inhibition of platelet function.  Blood.  1999 Sep 1;94(5):1693-700.

Maalej N, Albrecht R, Loscalzo J, Folts JD.  The potent platelet inhibitory effects of S-nitrosated albumin coating of artificial surfaces.  Journal of the American College of Cardiology.  1999 Apr;33(5):1408-14.

Zai A, Rudd MA, Scribner AW, Loscalzo J.  Cell-surface protein disulfide isomerase catalyzes transnitrosation and regulates intracellular transfer of nitric oxide.  Journal of Clinical Investigation.  1999 Feb;103(3):393-9.

Keaney JF Jr, Loscalzo J.  Diabetes, oxidative stress, and platelet activation.
Circulation.  1999 Jan 19;99(2):189-91.


Freedman JE, Ting B, Hankin B, Loscalzo J, Keaney JF Jr, Vita JA.  Impaired platelet production of nitric oxide predicts presence of acute coronary syndromes.  Circulation.  1998 Oct 13;98(15):1481-6.


Freedman JE, Loscalzo J, Barnard MR, Alpert C, Keaney JF, Michelson AD.  Nitric oxide released from activated platelets inhibits platelet recruitment.  Journal of Clinical Investigation.  1997 Jul 15;100(2):350-6.

Upchurch GR Jr, Welch GN, Freedman JE, Fabian AJ, Pigazzi A, Scribner AM, Alpert CS, Keaney JF Jr, Loscalzo J.  High-dose heparin decreases nitric oxide production by cultured bovine endothelial cells.  Circulation.  1997 Apr 15;95(8):2115-21.


Freedman JE, Farhat JH, Loscalzo J, Keaney JF Jr.  alpha-tocopherol inhibits aggregation of human platelets by a protein kinase C-dependent mechanism.  Circulation.  1996 Nov 15;94(10):2434-40.

Scharfstein JS, Abendschein DR, Eisenberg PR, George D, Cannon CP, Becker RC, Sobel B, Cupples LA, Braunwald E, Loscalzo J.  Usefulness of fibrinogenolytic and procoagulant markers during thrombolytic therapy in predicting clinical outcomes in acute myocardial infarction. TIMI-5 Investigators. Thrombolysis in Myocardial Infarction.  American Journal of Cardiology. 1996 Sep 1;78(5):503-10.

Loscalzo J.  Thrombin inhibitors in fibrinolysis. A Hobson's choice of alternatives.
Circulation. 1996 Sep 1;94(5):863-5.

Loscalzo J.  The oxidant stress of hyperhomocyst(e)inemia.  Journal of Clinical Investigation. 1996 Jul 1;98(1):5-7.

Freedman JE, Loscalzo J, Benoit SE, Valeri CR, Barnard MR, Michelson AD.  Decreased platelet inhibition by nitric oxide in two brothers with a history of arterial thrombosis.  Journal of Clinical Investigation. 1996 Feb 15;97(4):979-87.


Marks DS, Vita JA, Folts JD, Keaney JF Jr, Welch GN, Loscalzo J.  Inhibition of neointimal proliferation in rabbits after vascular injury by a single treatment with a protein adduct of nitric oxide.  Journal of Clinical Investigation. 1995 Dec;96(6):2630-8.

Khuri SF, Valeri CR, Loscalzo J, Weinstein MJ, Birjiniuk V, Healey NA, MacGregor H, Doursounian M, Zolkewitz MA.  Heparin causes platelet dysfunction and induces fibrinolysis before cardiopulmonary bypass.  Ann Thorac Surg. 1995 Oct;60(4):1008-14.

Nanji AA, Greenberg SS, Tahan SR, Fogt F, Loscalzo J, Sadrzadeh SM, Xie J, Stamler JS.  Nitric oxide production in experimental alcoholic liver disease in the rat: role in protection from injury.  Gastroenterology. 1995 Sep;109(3):899-907.

Zarich SW, Kowalchuk GJ, Weaver WD, Loscalzo J, Sassower M, Manzo K, Byrnes C, Muller JE, Gurewich V.  Sequential combination thrombolytic therapy for acute myocardial infarction: results of the Pro-Urokinase and t-PA Enhancement of Thrombolysis (PATENT) Trial.  Journal of the American College of Cardiologists. 1995 Aug;26(2):374-9.

Loscalzo J.  Nitric oxide and vascular disease.  New England Journal of Medicine. 1995 Jul 27;333(4):251-3.

Freedman JE, Frei B, Welch GN, Loscalzo J.  Glutathione peroxidase potentiates the inhibition of platelet function by S-nitrosothiols.  Journal of Clinical Investigation. 1995 Jul;96(1):394-400.

Hare JM, Keaney JF Jr, Balligand JL, Loscalzo J, Smith TW, Colucci WS.  Role of nitric oxide in parasympathetic modulation of beta-adrenergic myocardial contractility in normal dogs.  Journal of Clinical Investigation. 1995 Jan;95(1):360-6.


Loh E, Stamler JS, Hare JM, Loscalzo J, Colucci WS.  Cardiovascular effects of inhaled nitric oxide in patients with left ventricular dysfunction.  Circulation. 1994 Dec;90(6):2780-5.

Loscalzo J, Vita JA.  Ischemia, hyperemia, exercise, and nitric oxide. Complex physiology and complex molecular adaptations.  Circulation. 1994 Nov;90(5):2556-9.

Slivka A, Chuttani R, Carr-Locke DL, Kobzik L, Bredt DS, Loscalzo J, Stamler JS.  Inhibition of sphincter of Oddi function by the nitric oxide carrier S-nitroso-N-acetylcysteine in rabbits and humans.  Journal of Clinical Investigation. 1994 Nov;94(5):1792-8.

Scharfstein JS, Keaney JF Jr, Slivka A, Welch GN, Vita JA, Stamler JS, Loscalzo J.  In vivo transfer of nitric oxide between a plasma protein-bound reservoir and low molecular weight thiols.  Journal of Clinical Investigation. 1994 Oct;94(4):1432-9.

Keaney JF Jr, Shwaery GT, Xu A, Nicolosi RJ, Loscalzo J, Foxall TL, Vita JA.  17 beta-estradiol preserves endothelial vasodilator function and limits low-density lipoprotein oxidation in hypercholesterolemic swine.  Circulation. 1994 May;89(5):2251-9.

Rabbani LE, Edelman ER, Ganz P, Selwyn AP, Loscalzo J, Bittl JA.  Relation of restenosis after excimer laser angioplasty to fasting insulin levels.  American Journal of Cardiology. 1994 Feb 15;73(5):323-7.

Keaney JF Jr, Gaziano JM, Xu A, Frei B, Curran-Celentano J, Shwaery GT, Loscalzo J, Vita JA.  Low-dose alpha-tocopherol improves and high-dose alpha-tocopherol worsens endothelial vasodilator function in cholesterol-fed rabbits.  Journal of Clinical Investigation. 1994 Feb;93(2):844-51.

Pasche B, Ouimet H, Francis S, Loscalzo J.  Structural changes in platelet glycoprotein IIb/IIIa by plasmin: determinants and functional consequences.  Blood. 1994 Jan 15;83(2):404-14.


Sharma GV, Lapsley D, Vita JA, Sharma S, Coccio E, Adelman B, Loscalzo J.  Usefulness and tolerability of hirulog, a direct thrombin-inhibitor, in unstable angina pectoris.  American Journal of Cardiology. 1993 Dec 15;72(18):1357-60.

Rachmilewitz D, Stamler JS, Karmeli F, Mullins ME, Singel DJ, Loscalzo J, Xavier RJ, Podolsky DK.  Peroxynitrite-induced rat colitis--a new model of colonic inflammation.  Gastroenterology. 1993 Dec;105(6):1681-8.

Simon DI, Ezratty AM, Francis SA, Rennke H, Loscalzo J.  Fibrin(ogen) is internalized and degraded by activated human monocytoid cells via Mac-1 (CD11b/CD18): a nonplasmin fibrinolytic pathway.  Blood. 1993 Oct 15;82(8):2414-22.

Kestin AS, Valeri CR, Khuri SF, Loscalzo J, Ellis PA, MacGregor H, Birjiniuk V, Ouimet H, Pasche B, Nelson MJ, et al.  The platelet function defect of cardiopulmonary bypass.  Blood. 1993 Jul 1;82(1):107-17.

Cannon CP, Maraganore JM, Loscalzo J, McAllister A, Eddings K, George D, Selwyn AP, Adelman B, Fox I, Braunwald E, et al.  Anticoagulant effects of hirulog, a novel thrombin inhibitor, in patients with coronary artery disease.  American Journal of Cardiology. 1993 Apr 1;71(10):778-82.

Keaney JF Jr, Simon DI, Stamler JS, Jaraki O, Scharfstein J, Vita JA, Loscalzo J.  NO forms an adduct with serum albumin that has endothelium-derived relaxing factor-like properties.  Journal of Clinical Investigation. 1993 Apr;91(4):1582-9.

Stamler JS, Osborne JA, Jaraki O, Rabbani LE, Mullins M, Singel D, Loscalzo J.  Adverse vascular effects of homocysteine are modulated by endothelium-derived relaxing factor and related oxides of nitrogen.  Journal of Clinical Investigation. 1993 Jan;91(1):308-18.


McIntyre KM, Vita JA, Lambrew CT, Freeman J, Loscalzo J.  A noninvasive method of predicting pulmonary-capillary wedge pressure.  New England Journal of Medicine. 1992 Dec 10;327(24):1715-20.

Winther K, Hillegass W, Tofler GH, Jimenez A, Brezinski DA, Schafer AI, Loscalzo J, Williams GH, Muller JE.  Effects on platelet aggregation and fibrinolytic activity during upright posture and exercise in healthy men.  American Journal of Cardiology. 1992 Oct 15;70(11):1051-5.

Seed M, Loscalzo J.  Lipoprotein(a) and coronary heart disease.  BMJ. 1992 Aug 22;305(6851):472-3.

Loscalzo J.  Endothelial dysfunction in pulmonary hypertension.  New England Journal of Medicine. 1992 Jul 9;327(2):117-9.

Loscalzo J, Rocco TP.  Imaging arterial thrombi. An elusive goal.  Circulation. 1992 Jan;85(1):382-5.


Kirshenbaum JM, Bahr RD, Flaherty JT, Gurewich V, Levine HJ, Loscalzo J, Schumacher RR, Topol EJ, Wahr DW, Braunwald E.  Clot-selective coronary thrombolysis with low-dose synergistic combinations of single-chain urokinase-type plasminogen activator and recombinant tissue-type plasminogen activator. The Pro-Urokinase for Myocardial Infarction Study Group.  American Journal of Cardiology. 1991 Dec 15;68(17):1564-9.                                             

Rudd MA, Johnstone MT, Rabbani LE, George D, Ware JA, Loscalzo J.  Thrombolytic therapy causes an increase in vascular permeability that is reversed by 1-deamino-8-D-vasopressin.  Circulation. 1991 Dec;84(6):2568-73.

Cooke JP, Rossitch E Jr, Andon NA, Loscalzo J, Dzau VJ.  Flow activates an endothelial potassium channel to release an endogenous nitrovasodilator.  Journal of Clinical Investigation. 1991 Nov;88(5):1663-71.

Stamler JS, Vaughan DE, Loscalzo J.  Immunosuppressive therapy and lipoprotein abnormalities after cardiac transplantation.  American Journal of Cardiology. 1991 Aug 1;68(4):389-91.

Newburger JW, Burns JC, Beiser AS, Loscalzo J.  Altered lipid profile after Kawasaki syndrome.  Circulation. 1991 Aug;84(2):625-31.

Folts JD, Stamler J, Loscalzo J.  Intravenous nitroglycerin infusion inhibits cyclic Blood flow responses caused by periodic platelet thrombus formation in stenosed canine coronary arteries.  Circulation. 1991 Jun;83(6):2122-7.


Johnstone MT, Andrews T, Ware JA, Rudd MA, George D, Weinstein M, Loscalzo J.  Bleeding time prolongation with streptokinase and its reduction with 1-desamino-8-D-arginine vasopressin.  Circulation. 1990 Dec;82(6):2142-51.

Loscalzo J.  Regression of coronary atherosclerosis.  New England Journal of Medicine. 1990 Nov 8;323(19):1337-9.

Loscalzo J.  Molecular biologic modification of plasminogen activators. An artful science.  Circulation. 1990 Sep;82(3):1062-3.

Creager MA, Cooke JP, Mendelsohn ME, Gallagher SJ, Coleman SM, Loscalzo J, Dzau VJ.  Impaired vasodilation of forearm resistance vessels in hypercholesterolemic humans.  Journal of Clinical Investigation. 1990 Jul;86(1):228-34.


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