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Loscalzo Lab Publications


Loscalzo J.  The NIH budget and the future of biomedical research.  New England Journal of Medicine.  2006 Apr 20;354(16):1665-7.

Loscalzo J.  Homocysteine trials--clear outcomes for complex reasons.  New England Journal of Medicine.  2006 Apr 13;354(15):1629-32. Epub 2006 Mar 12.

Loscalzo J.  Joseph Loscalzo, MD, PhD: a conversation with the Editor.  American Journal of Cardiology.  2006 Apr 1;97(7):1110-22.  Epub 2006 Feb 13.

Kamath AF, Chauhan AK, Kisucka J, Dole VS, Loscalzo J, Handy DE, Wagner DD.  Elevated levels of homocysteine compromise Blood-brain barrier integrity in mice.  Blood.   2006 Jan 15;107(2):591-3.  Epub 2005 Sep 27.


Loscalzo J.  Clinical trials in cardiovascular medicine in an era of marginal benefit, bias, and hyperbole.  Circulation.  2005 Nov 15;112(20):3026-9.

Song Y, Jones JE, Beppu H, Keaney JF Jr, Loscalzo J, Zhang YY.  Increased susceptibility to pulmonary hypertension in heterozygous BMPR2-mutant mice.  Circulation.  2005 Jul 26;112(4):553-62.  Epub 2005 Jul 18.

Matsui R, Xu S, Maitland KA, Hayes A, Leopold JA, Handy DE, Loscalzo J, Cohen RA.  Glucose-6 phosphate dehydrogenase deficiency decreases the vascular response to angiotensin II.  Circulation.  2005 Jul 12;112(2):257-63.  Epub 2005 Jul 5.

Benjamin IJ, Arnett DK, Loscalzo J; American Heart Association Basic Science Writing Group.  Discovering the full spectrum of cardiovascular disease: Minority Health Summit 2003: report of the Basic Science Writing Group.  Circulation. 2005 Mar 15;111(10):e120-3.


Loscalzo J, Bonow RO, Jacobs AK.  Coronary calcium screening and the American Heart Association news embargo.  Circulation.  2004 Dec 7;110(23):3504-5.

Jacobs AK, Smith SC Jr, Popp RL, Loscalzo J.  Ethics and professionalism: can there be consensus? An editorial comment on the report of the ACCF/AHA Consensus Conference on Professionalism and Ethics.  Circulation. 2004 Oct 19;110(16):2278-9.

Faxon DP, Creager MA, Smith SC Jr, Pasternak RC, Olin JW, Bettmann MA, Criqui MH, Milani RV, Loscalzo J, Kaufman JA, Jones DW, Pearce WH; American Heart Association.  Atherosclerotic Vascular Disease Conference: Executive summary: Atherosclerotic Vascular Disease Conference proceeding for healthcare professionals from a special writing group of the American Heart Association.  Circulation.  2004 Jun 1;109(21):2595-604.

Voetsch B, Benke KS, Panhuysen CI, Damasceno BP, Loscalzo J.  The combined effect of paraoxonase promoter and coding region polymorphisms on the risk of arterial ischemic stroke among young adults.  Archives of Neurology.  2004 Mar;61(3):351-6.

Jain M, Cui L, Brenner DA, Wang B, Handy DE, Leopold JA, Loscalzo J, Apstein CS, Liao R.  Increased myocardial dysfunction after ischemia-reperfusion in mice lacking glucose-6-phosphate dehydrogenase.  Circulation.  2004 Feb 24;109(7):898-903.  Epub 2004 Feb 2.

Loscalzo J.  Ozone--from environmental pollutant to atherogenic determinant.
New England Journal of Medicine.  2004 Feb 19;350(8):834-5.


Loscalzo J.  Functional polymorphisms in a candidate gene for atherothrombosis: unraveling the complex fabric of a polygenic phenotype.  Journal of the American College of Cardiology.  2003 Mar 19;41(6):946-8.


Loscalzo J, Balaban R, Becker LB, Ginsburg GS, Hachinski VC, Hall JE, Heistad DD, Leinwand LA, Lenfant CJ, Marban E, Olson EN, Schwartz SM; American Heart Association. Task Force on Strategic Research Direction. Basic Science Subgroup.  Task Force on Strategic Research Direction: Basic Science Subgroup key science topics report.  Circulation.  2002 Nov 12;106(20):e149-61.

Roberts R, Bonow RO, Loscalzo J, Mosca L; American Heart Association Task Force on Strategic Research Direction.  Report of the American Heart Association Task Force on Strategic Research Direction: executive summary.  Circulation.  2002 Nov 12;106(20):2630-2.

Napoli C, Lerman LO, de Nigris F, Loscalzo J, Ignarro LJ.  Glycoxidized low-density lipoprotein downregulates endothelial nitricoxide synthase in human coronary cells.  Journal of the American College of Cardiology.  2002 Oct 16;40(8):1515-22.

Tawakol A, Forgione MA, Stuehlinger M, Alpert NM, Cooke JP, Loscalzo J, Fischman AJ, Creager MA, Gewirtz H.  Homocysteine impairs coronary microvascular dilator function in humans.  Journal of the American College of Cardiology.  2002 Sep 18;40(6):1051-58.

Forgione MA, Cap A, Liao R, Moldovan NI, Eberhardt RT, Lim CC, Jones J, Goldschmidt-Clermont PJ, Loscalzo J.  Heterozygous cellular glutathione peroxidase deficiency in the mouse: abnormalities in vascular and cardiac function and structure.  Circulation.  2002 Aug 27;106(9):1154-8.

Vita JA, Loscalzo J.  Shouldering the risk factor burden: infection, atherosclerosis, and the vascular endothelium.  Circulation.  2002 Jul 9;106(2):164-6.

Freedman JE, Loscalzo J.  Platelet-monocyte aggregates: bridging thrombosis and inflammation.  Circulation.  2002 May 7;105(18):2130-2.

Sawyer DB, Loscalzo J.  Myocardial hibernation: restorative or preterminal sleep?  Circulation.  2002 Apr 2;105(13):1517-9.

Loscalzo J.  Homocysteine and dementias.  New England Journal of Medicine.  2002 Feb 14;346(7):466-8.


Loscalzo J.  Folate and nitrate-induced endothelial dysfunction: a simple treatment for a complex pathobiology.  Circulation. 2001 Sep 4;104(10):1086-8.

Loscalzo J.  An experiment of nature: genetic L-arginine deficiency and NO insufficiency.  Journal of Clinical Investigation.  2001 Sep;108(5):663-4.

Loscalzo J.  Genetic clues to the cause of primary pulmonary hypertension.  New England Journal of Medicine.  2001 Aug 2;345(5):367-71.

Loscalzo J.  Resolution of platelet-rich thrombi in essential thrombocythemia: mechanisms, risks, and benefits of antiplatelet therapy.  Mayo Clinic Proceedings.  2001 Apr;76(4):356-7.


Eberhardt RT, Forgione MA, Cap A, Leopold JA, Rudd MA, Trolliet M, Heydrick S, Stark R, Klings ES, Moldovan NI, Yaghoubi M, Goldschmidt-Clermont PJ, Farber HW, Cohen R, Loscalzo J.  Endothelial dysfunction in a murine model of mild hyperhomocyst(e)inemia.  Journal of Clinical Investigation.  2000 Aug;106(4):483-91.

Battinelli E, Loscalzo J.  Nitric oxide induces apoptosis in megakaryocytic cell lines.  Blood.  2000 Jun 1;95(11):3451-9.

Yang Y, Loscalzo J.  Regulation of tissue factor expression in human microvascular endothelial cells by nitric oxide.  Circulation.  2000 May 9;101(18):2144-8.

Loscalzo J.  What we know and don't know about L-arginine and NO.  Circulation.  2000 May 9;101(18):2126-9.

Loscalzo J.  Vascular matrix and vein graft failure. Is the message in the medium?  Circulation.  2000 Jan 25;101(3):221-3.


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